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Determining which type of diabetes a patient has is critical in providing the proper care and treatment. However, a rise in childhood obesity has made distinguishing between type 1 and type 2 diabetes increasingly more challenging.4 Additionally, MODY is often misdiagnosed as Type 1 or Type 2 diabetes due to the similarities in clinical presentation.5 In fact, up to 95% of MODY diabetes cases are misdiagnosed, and these patients may receive inappropriate treatment.2,5
According to the American Diabetes Association, physicians should consider testing patients who were diagnosed in youth or early adulthood and have a strong family history of diabetes. Additionally, patients who were diagnosed with diabetes in youth or early adulthood, but do not present with typical features of Type 1 or Type 2 diabetes, may also benefit from testing. Patients with atypical characteristics may3:
Most people diagnosed with MODY have impaired insulin secretion and typically experience onset before they are 25 years old.3 The four most common forms of MODY are caused by mutations in HNF1A (MODY3), GCK (MODY2), HNF4A (MODY1), and HNF1B (MODY5).3,6
Depending on the form of MODY, patients may be able to switch from potentially painful and expensive insulin injections to an oral medication, which is typically less expensive and may be a more appealing option to most patients.2 In addition to optimizing treatment, correctly diagnosing MODY can assist in diagnosing other affected family members and predicting the prognosis of the disease.3 A specific MODY diagnosis can also explain symptoms other than diabetes and allow for increased surveillance of associated complications.3
Learn more about the development of our MODY assay in our new Meet the Maker Q&A series.
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